https://jiomics.com/index.php/jiomics <div class="mainrow"> <div class="homeImageMini">JIOMICS provides a forum for the publication of original research papers, letters to the editor, short communications, and critical reviews in all branches of pure and applied –omics subjects, such as proteomics, metabolomics, metallomics and genomics. Especial interest is given to papers where more than one –omics subject is covered. Papers are evaluated based on scientific novelty and demonstrated scientific applicability. Original research papers on fundamental studies, and novel sensor and instrumentation development, are especially encouraged. Novel or improved findings in areas such as clinical, medicinal, biological, environmental and materials –omics are welcome.</div> <div class="homeImageMini"> <div class="homeImageMini"> </div> <div class="homeDescription"> <table style="height: 144px; width: 100%; border-collapse: collapse;" border="0"> <tbody> <tr style="height: 18px;"> <td style="width: 50%; height: 18px;"><a href="https://www.jiomics.com/index.php/jiomics/issue/current">Current Issue</a></td> <td style="width: 50%; height: 18px; text-align: right;"><a href="https://www.jiomics.com/index.php/jiomics/issue/archive">Previous issues</a></td> </tr> <tr style="height: 18px;"> <td style="width: 50%; height: 18px;"><a href="https://www.jiomics.com/index.php/jiomics/issue/archive">Accepted manuscripts</a></td> <td style="width: 50%; height: 18px; text-align: right;"><a href="https://www.jiomics.com/index.php/jiomics/about">Editorial Board</a></td> </tr> <tr style="height: 18px;"> <td style="width: 50%; height: 18px;"><a href="https://www.jiomics.com/index.php/jiomics/about/submissions#onlinesubmissions">Guide for authors</a></td> <td style="width: 50%; height: 18px; text-align: right;"><a href="https://www.jiomics.com/index.php/jiomics/about/submissions#templateforonlinesubmissions">Template for submissions</a></td> </tr> <tr style="height: 18px;"> <td style="width: 50%; height: 18px;"><a href="https://www.jiomics.com/index.php/jiomics/about/submissions#templateforonlinesubmissions">JIOMICS references format</a></td> <td style="width: 50%; height: 18px; text-align: right;"><a href="https://www.jiomics.com/index.php/jiomics/about/submissions#authorfees">Fees</a></td> </tr> </tbody> </table> </div> </div> </div> Proteomass en-US Journal of Integrated OMICS 2182-0287 https://jiomics.com/index.php/jiomics/article/view/239 <p style="font-weight: 400;">SARS-CoV-2 bio-surveillance at all levels is crucial for understanding its genetic evolution and vaccine effectiveness.This study investigated the emergence and evolution of new SARS-CoV-2 variants in the city of Puducherry, India throughout the three peaks of infection. A total of 128 samples were subjected to Illumina deep RNA sequencing. The results indicate that the first wave was dominated by uncommon variants, the second by Delta, and the third by Omicron. Lineages B.1.560 and B.1.617.2 were most prevalent. Analysis of 3133 common and 11 new mutations revealed Spike_D614G as the most common mutation and a novel set of mutations was observed in NS16, a key immune evasion factor. These NS16 mutations raise concerns about increased virulence, reduced vaccine efficacy, and potential antiviral resistance, warranting further investigation. Our findings contribute to SARS-CoV-2 evolutionary and genetic epidemiology research and highlight the need for ongoing surveillance to anticipate future variant threats.</p> Vanathy K Agieshkumar Balakrishna Pillai Vignesh Mariappan Malarvizhi Ramalingam Pajanivel Raganadin Ramya Ramadoss Balasubramanian Moovarkumudalvan Joshy M Easow Madavan Vasudevan S.R. Rao Copyright (c) 2025 Journal of Integrated OMICS https://creativecommons.org/licenses/by/4.0 2025-06-12 2025-06-12 15 2 1 10 10.5584/jiomics.v15i2.239 https://jiomics.com/index.php/jiomics/article/view/244 José Luís Capelo Martínez Copyright (c) 2025 Journal of Integrated OMICS https://creativecommons.org/licenses/by/4.0 2025-06-12 2025-06-12 15 2 1 13 10.5584/jiomics.v15i2.244 https://jiomics.com/index.php/jiomics/article/view/246 Carlos Lodeiro José Luís Capelo Martínez Federica Pelatti Daphné Chopard Lena Voith von Voithenberg Nir Peled Gianluca Moroncini Laura Mercolini Cristina Zibetti Tian-Li Wang Tânia Morais Gamze Gürsoy Daniele Lo Re Luís Perpétuo Erica Quagliarini Rong Fan Rossella De Marco Leandro Teodoro Júnior Stavroula Baritaki Michael Sherman Anna Bielecka Wajdman Marco Tutone Varum Kumar Nomula Sobia Noreen Copyright (c) 2025 Journal of Integrated OMICS https://creativecommons.org/licenses/by/4.0 2025-06-12 2025-06-12 15 2 11 13 10.5584/jiomics.v15i2.246