Journal of Integrated OMICS https://jiomics.com/index.php/jiomics <div class="mainrow"> <div class="homeImageMini">JIOMICS provides a forum for the publication of original research papers, letters to the editor, short communications, and critical reviews in all branches of pure and applied –omics subjects, such as proteomics, metabolomics, metallomics and genomics. Especial interest is given to papers where more than one –omics subject is covered. Papers are evaluated based on scientific novelty and demonstrated scientific applicability. Original research papers on fundamental studies, and novel sensor and instrumentation development, are especially encouraged. Novel or improved findings in areas such as clinical, medicinal, biological, environmental and materials –omics are welcome.</div> <div class="homeImageMini"> <div class="homeImageMini"> </div> <div class="homeDescription"> <table style="height: 144px; width: 100%; border-collapse: collapse;" border="0"> <tbody> <tr style="height: 18px;"> <td style="width: 50%; height: 18px;"><a href="https://www.jiomics.com/index.php/jiomics/issue/current">Current Issue</a></td> <td style="width: 50%; height: 18px; text-align: right;"><a href="https://www.jiomics.com/index.php/jiomics/issue/archive">Previous issues</a></td> </tr> <tr style="height: 18px;"> <td style="width: 50%; height: 18px;"><a href="https://www.jiomics.com/index.php/jiomics/issue/archive">Accepted manuscripts</a></td> <td style="width: 50%; height: 18px; text-align: right;"><a href="https://www.jiomics.com/index.php/jiomics/about">Editorial Board</a></td> </tr> <tr style="height: 18px;"> <td style="width: 50%; height: 18px;"><a href="https://www.jiomics.com/index.php/jiomics/about/submissions#onlinesubmissions">Guide for authors</a></td> <td style="width: 50%; height: 18px; text-align: right;"><a href="https://www.jiomics.com/index.php/jiomics/about/submissions#templateforonlinesubmissions">Template for submissions</a></td> </tr> <tr style="height: 18px;"> <td style="width: 50%; height: 18px;"><a href="https://www.jiomics.com/index.php/jiomics/about/submissions#templateforonlinesubmissions">JIOMICS references format</a></td> <td style="width: 50%; height: 18px; text-align: right;"><a href="https://www.jiomics.com/index.php/jiomics/about/submissions#authorfees">Fees</a></td> </tr> </tbody> </table> </div> </div> </div> Proteomass en-US Journal of Integrated OMICS 2182-0287 Vol. 11, No. 2 (2021) https://jiomics.com/index.php/jiomics/article/view/206 J. L. Capelo Copyright (c) 2021 Journal of Integrated OMICS https://creativecommons.org/licenses/by/4.0 2021-12-29 2021-12-29 11 2 1 28 10.5584/jiomics.v11i2.206 Human disease biomarkers: challenges, advances, and trends in their validation https://jiomics.com/index.php/jiomics/article/view/207 <p>Biomarkers are important tools in the medical field, once they allow better prediction, characterization, and treatment of diseases. In this scenario, it is essential that biomarkers are highly accurate. Thus, biomarker validation is an essential part of ensuring the effectiveness of a biomarker. Validation of biomarkers is the process by which biomarkers are evaluated for accuracy and consistency, as well as their ability to inform the condition of health or disease. Although, there is no unique measure that can be used to determine the validity for all biomarkers, there are general criteria that all biomarkers must meet to be useful. In this work, we review the definition of biomarkers and discuss the validity components. We then critically discuss the main methods used to validate biomarkers and consider some examples of biomarkers of the diseases which most killer in the world (cardiovascular diseases, cancer, and viral infections), highlighting the potential biochemical pathways of these biomarkers in the biological system. In addition, we also comment on the omic strategies used in the biomarker discovery process and conclude with information about perspectives in biomarker validation through imaging techniques.</p> J. R. de Jesus Marco Arruda Copyright (c) 2021 Journal of Integrated OMICS https://creativecommons.org/licenses/by/4.0 2021-12-29 2021-12-29 11 2 16 28 10.5584/jiomics.v11i2.207 SPECIAL ISSUE: SELECTED ABSTRACTS OF OF THE IV INTERNATIONAL CAPARICA CONFERENCE IN SPLICING (SPLICING 2021) and OF THE VII INTERNATIONAL CAPARICA CONFERENCE ON ANALYTICAL PROTEOMICS (ICAP 2021) https://jiomics.com/index.php/jiomics/article/view/205 <p>SPECIAL ISSUE: SELECTED ABSTRACTS OF OF THE IV INTERNATIONAL CAPARICA CONFERENCE IN SPLICING (SPLICING 2021) and OF THE VII INTERNATIONAL CAPARICA CONFERENCE ON ANALYTICAL PROTEOMICS (ICAP 2021)</p> J.L. Capelo Copyright (c) 2021 Journal of Integrated OMICS https://creativecommons.org/licenses/by/4.0 2021-12-29 2021-12-29 11 2 1 15 10.5584/jiomics.v11i2.205