https://jiomics.com/index.php/jiomics <div class="mainrow"> <div class="homeImageMini">JIOMICS provides a forum for the publication of original research papers, letters to the editor, short communications, and critical reviews in all branches of pure and applied –omics subjects, such as proteomics, metabolomics, metallomics and genomics. Especial interest is given to papers where more than one –omics subject is covered. Papers are evaluated based on scientific novelty and demonstrated scientific applicability. Original research papers on fundamental studies, and novel sensor and instrumentation development, are especially encouraged. Novel or improved findings in areas such as clinical, medicinal, biological, environmental and materials –omics are welcome.</div> <div class="homeImageMini"> <div class="homeImageMini"> </div> <div class="homeDescription"> <table style="height: 144px; width: 100%; border-collapse: collapse;" border="0"> <tbody> <tr style="height: 18px;"> <td style="width: 50%; height: 18px;"><a href="https://www.jiomics.com/index.php/jiomics/issue/current">Current Issue</a></td> <td style="width: 50%; height: 18px; text-align: right;"><a href="https://www.jiomics.com/index.php/jiomics/issue/archive">Previous issues</a></td> </tr> <tr style="height: 18px;"> <td style="width: 50%; height: 18px;"><a href="https://www.jiomics.com/index.php/jiomics/issue/archive">Accepted manuscripts</a></td> <td style="width: 50%; height: 18px; text-align: right;"><a href="https://www.jiomics.com/index.php/jiomics/about">Editorial Board</a></td> </tr> <tr style="height: 18px;"> <td style="width: 50%; height: 18px;"><a href="https://www.jiomics.com/index.php/jiomics/about/submissions#onlinesubmissions">Guide for authors</a></td> <td style="width: 50%; height: 18px; text-align: right;"><a href="https://www.jiomics.com/index.php/jiomics/about/submissions#templateforonlinesubmissions">Template for submissions</a></td> </tr> <tr style="height: 18px;"> <td style="width: 50%; height: 18px;"><a href="https://www.jiomics.com/index.php/jiomics/about/submissions#templateforonlinesubmissions">JIOMICS references format</a></td> <td style="width: 50%; height: 18px; text-align: right;"><a href="https://www.jiomics.com/index.php/jiomics/about/submissions#authorfees">Fees</a></td> </tr> </tbody> </table> </div> </div> </div> Proteomass en-US Journal of Integrated OMICS 2182-0287 https://jiomics.com/index.php/jiomics/article/view/240 José Luís Capelo Martínez Carlos Lodeiro Sofia Pessanha Abel J. S. C. Vieira Maria Rosa Paiva Renata Freitas Isabel Fonseca Manuel D. Ortigueira Mauro Guerra Luís Lapão Copyright (c) 2025 Journal of Integrated OMICS https://creativecommons.org/licenses/by/4.0 2025-04-14 2025-04-14 15 1 1 4 10.5584/jiomics.v15i1.240 https://jiomics.com/index.php/jiomics/article/view/245 <p>A comparative urinary proteomic analysis using the Total Protein Approach (TPA) revealed distinct protein abundance profiles between patients with muscle-invasive (MIBC) and non-muscle-invasive bladder cancer (NMIBC), suggesting potential diagnostic utility. Notably, several proteins, including periostin (POSTN), immunoglobulin variable regions (IGLV3-21, IGHV3-49, IGHV5-51), and complement regulator (C4BPB), were found at significantly higher concentrations in the urine of MIBC patients. These findings support their value as non-invasive indicators of tumour aggressiveness. The TPA-based urinary protein signature holds promise for improving early risk stratification, detecting biological features associated with invasive disease, and may inform treatment strategies.</p> João M. R. A. Montes Luís B. Carvalho Inês F. Domingos André Q. Figueiredo Carlos Lodeiro Mariana Medeiros Luís Campos Pinheiro José Luís Capelo Martínez Hugo M. Santos Copyright (c) 2025 Journal of Integrated OMICS https://creativecommons.org/licenses/by/4.0 2025-04-14 2025-04-14 15 1 5 11 10.5584/jiomics.v15i1.245