Bioradical homeostasis as new complex parameters of different biological systems

DOI: 10.5584/jiomics.v10i2.328

Abstract

The current state of free radical biomedicine allows us to formulate a fundamentally new parameter of homeostasis – bioradical homeostasis, understood as a state of free radical processes, reflecting the optimal intensity of the body metabolism of oxygen, nitrogen and halogens reactive species, carbonyls and other radical molecules. This term allows us to formulate another term – "bioradical stress". It is proposed to understand the effective violation of the physiological level of free-radical processes associated with the formation of active forms of oxygen, nitrogen or halogens and/or a decrease in the activity of systems that limit their damaging effect. It combines all known syndromes associated with bioradical level shifts (oxidative, nitrosative, halogenating and carbonyl stress). The introduction of the concept of bioradical stress involves the study of the effectiveness of various options for specific pathogenetic correction of bioradical stress (the administration of antioxidants, directed stimulation of antioxidant capacity by active oxygen forms, the use of regulatory properties of NO, etc.).